D1R antagonist 2

D1R antagonist 2 (Compound 13a) is a BBB-penetrable D1R antagonist with IC50s of 35.6 and 70 nM for cAMP-based D1R and β-arrestin-based D1R, respectively. D1R antagonist 2 effectively antagonizes D1R-mediated cAMP and β-arrestin recruitment. D1R antagonist 2 can be used for neurodegenerative and neuropsychiatric diseases such as schizophrenia, Parkinson’s disease and Alzheimer’s disease research[1].

Product Specifications

UNSPSC

12352005

Target

Arrestin; Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

FC(F)COC1=C(O)C=C([C@H](CC2=C(Br)C=C(O)C(OCC)=C2C3)N3CC4)C4=C1

Molecular Formula

C21H22BrF2NO4

Molecular Weight

470.30

References & Citations

[1]Namballa HK, et al. Fluoroalkoxylated C-3 and C-9 (S) -12-bromostepholidine analogues with D1R antagonist activity. Bioorg Chem. 2023 Dec;141:106862.