WRS22
WRS22, a derivative of Tirabrutinib (HY-15771), is a bacterial Tryptophanyl-tRNA synthetase (TrpRS) inhibitor with a Kd of 0.33 μM for EcTrpRS. WRS22 can be used for antibiotic resistance research[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Drug Derivative
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
FC1=C(C=C(C(O)=C1)OC2=CC=C(C=C2)N3C(N(C4=NC=NC(N)=C43)C5CCNCC5)=O)CNC(CC6CCCC(N6)=O)=O
Molecular Formula
C30H33FN8O5
Molecular Weight
604.63
References & Citations
[1]Xia K, et al. Structure-based design of tirabrutinib derivatives as inhibitors of bacterial tryptophanyl-tRNA synthetase. Bioorg Chem. 2025 Sep 9;165:108978.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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