Apoptosis inducer 45
Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
[H][C@]1(C(CC[C@@]2(C(C)([C@@H](CC[C@@]12C)O)C)[H])=C)CC/C(C)=C/C(N3CCN(CC3)CC4=CC=C(C=C4)C(NCCC5=CC=C(C=C5)C)=O)=O
Molecular Formula
C41H57N3O3
Molecular Weight
639.91
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; Caspase 8; Caspase 9; PARP
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