TEAD-IN-21

TEAD-IN-21 is a potent and orally active pan-TEAD inhibitor with an IC50 of 3 nM. TEAD-IN-21 effectively inhibited the proliferation of Huh-7 cells. TEAD-IN-21 selectively downregulates TEAD-dependent downstream genes. TEAD-IN-21 achieves tumor regression in a liver cancer-derived tumor xenograft mice model. TEAD-IN-21 can be used in the research of hepatocellular carcinoma (HCC) [1].

Product Specifications

UNSPSC

12352005

Target

YAP

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CS(=O)(NC1=CC=C(NC2=CC=C(C(F)(F)F)C=C2)C(C3=NN(C)N=N3)=C1)=O

Molecular Formula

C16H15F3N6O2S

Molecular Weight

412.39

References & Citations

[1]Lu Y, et al. Discovery and characterization of sulfonamide derivatives as transcriptional enhanced associate domain (TEAD) inhibitors: a novel approach for targeting hepatocellular carcinoma. Bioorg Chem. 2025 Aug 28;165:108911.