L-731120
L-731120 is an alkyl citrate zargozaga acid A analogue, which is secondary metabolite produced by fungal fermentation. L-731120 shows inhibitory activity against squalene synthase (SQS) (IC50 = 260 nM) . L-731120 can inhibit the synthesis of cholesterol in the liver. L-731120 can be used for the research of infection and metabolic disease, such as hypercholesterolemia[1].
Product Specifications
CAS Number
2232226-16-1
UNSPSC
12352211
Target
Drug Derivative; Drug Metabolite; Fungal
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Infection; Metabolic Disease
Smiles
O[C@@](CC(O)=O)([C@H](CCCCC/C(C)=C/[C@@H](CC1=CC=CC=C1)C)C(O)=O)C(O)=O
Molecular Formula
C23H32O7
Molecular Weight
420.50
References & Citations
[1]Harris G H, et al. Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5 (20) : 2403-2408.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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