Phthalimidinoglutarimide-5-piperazine-COC2-alkynes
Phthalimidinoglutarimide-5-piperazine-COC2-alkynes is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC BCL-xL/BCL-w Degrader 1 (HY-178066) . PROTAC BCL-xL/BCL-w Degrader 1 is a potent BCL-xL/BCL-w PROTAC degrader with anti-cancer activity[1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
C#CCCC(N1CCN(C2=CC=C(C(N(C3CCC(NC3=O)=O)C4)=O)C4=C2)CC1)=O
Molecular Formula
C22H24N4O4
Molecular Weight
408.45
References & Citations
[1]Poddar SK, et al. Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis (sulfonyl) benzene Ring of ABT-263 as a Linkage Vector. J Med Chem. 2025 Sep 11;68 (17) :18684-18702.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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