Phthalimidinoglutarimide-5-piperazine-COC2-alkynes

Phthalimidinoglutarimide-5-piperazine-COC2-alkynes is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC BCL-xL/BCL-w Degrader 1 (HY-178066) . PROTAC BCL-xL/BCL-w Degrader 1 is a potent BCL-xL/BCL-w PROTAC degrader with anti-cancer activity[1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

C#CCCC(N1CCN(C2=CC=C(C(N(C3CCC(NC3=O)=O)C4)=O)C4=C2)CC1)=O

Molecular Formula

C22H24N4O4

Molecular Weight

408.45

References & Citations

[1]Poddar SK, et al. Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis (sulfonyl) benzene Ring of ABT-263 as a Linkage Vector. J Med Chem. 2025 Sep 11;68 (17) :18684-18702.