PROTAC BCL-xL/BCL-w Degrader 1
PROTAC BCL-xL/BCL-w Degrader 1 (Compound 44) is a BCL-xL/BCL-w PROTAC degrader. PROTAC BCL-xL/BCL-w Degrader 1 has significant anticancer activity with reduced on-target platelet toxicity [1]. Pink: BCL-xL/BCL-w ligand (HY-10087) ; Blue: CRBN ligase ligand (HY-163233) ; Black: linker (HY-Y1230)
Product Specifications
UNSPSC
12352005
Target
Bcl-2 Family; PROTACs
Related Pathways
Apoptosis; PROTAC
Field of Research
Cancer
Smiles
ClC(C=C1)=CC=C1C2=C(CN3CCN(C4=CC=C(C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C(C#CCCC(N8CCN(C9=CC=C(C(N(C%10CCC(NC%10=O)=O)C%11)=O)C%11=C9)CC8)=O)=C5)=O)=O)C=C4)CC3)CC(C)(C)CC2
Molecular Formula
C69H77ClF3N9O10S3
Molecular Weight
1381.05
References & Citations
[1]Poddar SK, et al. Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis (sulfonyl) benzene Ring of ABT-263 as a Linkage Vector. J Med Chem. 2025 Sep 11;68 (17) :18684-18702.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-W; Bcl-xL
Curated Selection
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