PROTAC G9a/GLP degrader 1
PROTAC G9a/GLP degrader 1 is a G9a/GLP PROTAC degrader with DC50s of 336 nM (G9a) and 988 nM (GLP). PROTAC G9a/GLP degrader 1 exhibits inhibitory activity against G9a with an IC50 of 98 nM. PROTAC G9a/GLP degrader 1 effectively inhibits the migration of breast cancer MCF-7 cells without inhibiting cell proliferation. PROTAC G9a/GLP degrader 1 can be used for the study of breast cancer (Pink: G9a/GLP ligand ; Blue: VHL ligand (HY-125845) ; Black: Linker (HY-140468) ).
Product Specifications
UNSPSC
12352005
Target
GLP Receptor; Histone Methyltransferase; PROTACs
Related Pathways
Epigenetics; GPCR/G Protein; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
Molecular Formula
C57H76N8O11S
Molecular Weight
1081.33
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EHMT1/GLP/KMT1D; EHMT2/G9a/KMT1C; von Hippel-Lindau (VHL)
Frequently Asked Questions
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