DNA polymerase-IN-7
DNA polymerase-IN-7 is a noncompetitive inhibition of DNA Polymerase β with an IC50 of 112 nM and a Ki of 35 nM. DNA polymerase-IN-7 can inhibit DNA pol β lyase activity and the binding of the lyase domain of Pol β to DNA. DNA polymerase-IN-7 can be used for the research of cancer, such as cervical cancer[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C2=CC=C(C3=CC=C(C4=CC=C(O)C=C4)C=C3)C=C2)C=C1)N[C@H]5C[C@H](N6C=C(CCCNC(C7=CN8C(C=C(C)C=C8)=N7)=O)C(NC6=O)=O)O[C@@H]5COP([O-])(OC)=O.[NH4+]
Molecular Formula
C47H48N7O10P
Molecular Weight
901.90
References & Citations
[1]Howlader AH, et al. Noncompetitive Inhibition of DNA Polymerase β by a Nonnative Nucleotide. J Org Chem. 2025 Sep 19;90 (37) :12849-12859.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNA Polymerases
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