DGKα-IN-10

DGKα-IN-10 is an orally active and potent DGKα inhibitor with an IC50 of 0.27 nM. DGKα-IN-10 can induce IL-2 release and T cells proliferation. DGKα-IN-10 can be used for the research of cancer, such as colon cancer[1].

Product Specifications

CAS Number

[2980579-79-9]

UNSPSC

12352005

Target

DGK; Interleukin Related

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

N#CC1=NC2=C(N(C)C(C=C2N3CCC(C4=NC5=CC(C)=CC=C5O4)CC3)=O)C=C1OCCO

Molecular Formula

C25H25N5O4

Molecular Weight

459.50

References & Citations

[1]Lu H, et al. Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors. J Med Chem. 2025 Sep 25;68 (18) :19645-19660.