VU6080824 (hydrochloride)
VU6080824 (hydrochloride), a derivative of ML-133 (HY-100230), is an inward-rectifier potassium channel (Kir2.1) inhibitor with an IC50 of 0.35 μM. VU6080824 (hydrochloride) has superior thallium flux and manual patch clamp (MPC) functional potency[1].
Product Specifications
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Purity
98.88
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C=C1)CNCC2=CC=C(C3=CC=CC(OC)=C3)C=C2.Cl
Molecular Formula
C22H24ClNO2
Molecular Weight
369.88
References & Citations
[1]Duncan RA, et al. Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel Kir2.1: Discovery of VU6080824. ACS Med Chem Lett. 2025 Aug 29;16 (9) :1762-1771.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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