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VU6080824

VU6080824 (Compound 5s), a derivative of ML-133 , is an inward-rectifier potassium channel (Kir2.1) inhibitor with an IC50 of 0.35 μM. VU6080824 has superior thallium flux and manual patch clamp (MPC) functional potency[1].

Product Specifications

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Smiles

COC1=CC=C(C=C1)CNCC2=CC=C(C3=CC=CC(OC)=C3)C=C2

Molecular Formula

C22H23NO2

Molecular Weight

333.42

References & Citations

[1]Duncan RA, et al. Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel Kir2.1: Discovery of VU6080824. ACS Med Chem Lett. 2025 Aug 29;16 (9) :1762-1771.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Inwardly rectifying potassium channel

Frequently Asked Questions

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