Neuroprotective agent 14
Neuroprotective agent 14 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 14 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 14 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs) [1].
Product Specifications
CAS Number
[3086460-57-0]
UNSPSC
12352005
Target
Autophagy
Related Pathways
Autophagy
Field of Research
Neurological Disease
Smiles
CC1=NC2=C(C=C(C=C2)OCC3=CC=C(C=C3)C(F)(F)F)N1
Molecular Formula
C16H13F3N2O
Molecular Weight
306.28
References & Citations
[1]Simeon P, et al. Discovery of Functionalized 1H-Benzo[d]imidazoles That Confer Protective Effects in a Phenotypic CLN3 Disease Patient-Derived iPSC Model. J Med Chem. 2025 Sep 11;68 (17) :18530-18552.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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