UM-259
UM-259 is a STING inhibitor, with an EC50 of 1.50 μM in THP1-Dual cells expressing wild-type STING. UM-259 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6 and reducing IFNβ secretion. UM-259 can be used for the study of STING-dependent inflammatory and neurological diseases[1].
Product Specifications
UNSPSC
12352005
Target
IFNAR; Interleukin Related; STING
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=NOC(C2=CC=C(F)C=C2F)=C1)NC3(C4=NC5=CC=CC=C5N4)CCN(C(C6=CC=C([N+]([O-])=O)O6)=N)CC3
Molecular Formula
C27H21F2N7O5
Molecular Weight
561.50
References & Citations
[1]Barasa L, et al. Nitrofuran-Based STING Inhibitors. ACS Omega. 2025 Sep 4;10 (36) :41693-41706.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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