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UM-242

UM-242 is a STING inhibitor, with an EC50 of 1.70 μM in THP1-Dual cells expressing wild-type STING. UM-242 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6 and reducing IFNβ secretion. UM-242 can be used for the study of STING-dependent inflammatory and neurological diseases[1].

Product Specifications

UNSPSC

12352005

Target

IFNAR; Interleukin Related; STING

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=NOC(C2=CC(F)=CC=C2F)=N1)N[C@H](C3=NC4=CC=CC=C4N3)CCNC(C5=CC=C([N+]([O-])=O)O5)=N

Molecular Formula

C24H18F2N8O5

Molecular Weight

536.45

References & Citations

[1]Barasa L, et al. Nitrofuran-Based STING Inhibitors. ACS Omega. 2025 Sep 4;10 (36) :41693-41706.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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