UM-242
UM-242 is a STING inhibitor, with an EC50 of 1.70 μM in THP1-Dual cells expressing wild-type STING. UM-242 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6 and reducing IFNβ secretion. UM-242 can be used for the study of STING-dependent inflammatory and neurological diseases[1].
Product Specifications
UNSPSC
12352005
Target
IFNAR; Interleukin Related; STING
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=NOC(C2=CC(F)=CC=C2F)=N1)N[C@H](C3=NC4=CC=CC=C4N3)CCNC(C5=CC=C([N+]([O-])=O)O5)=N
Molecular Formula
C24H18F2N8O5
Molecular Weight
536.45
References & Citations
[1]Barasa L, et al. Nitrofuran-Based STING Inhibitors. ACS Omega. 2025 Sep 4;10 (36) :41693-41706.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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