MYC-IN-4

MYC-IN-4 is a MYC inhibitor. MYC-IN-4 impairs MYC/MAX protein-protein interaction (IC50 = 3.06 μM) . MYC-IN-4 inhibits MYC-aberrant PC-3 prostate cancer cells with an IC50 of 0.440 μM. MYC-IN-4 demonstrates potent antitumor efficacy in FVB mice bearing Myc-CaP prostate tumor allografts. MYC-IN-4 can be used for the study of prostate cancer[1].

Product Specifications

UNSPSC

12352005

Target

C-Myc

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

FC(F)(F)C(C=C1)=CC=C1C(O2)=CC3=C2C=CC(C4=CC(C(F)(F)F)=NN4)=C3

Molecular Formula

C19H10F6N2O

Molecular Weight

396.29

References & Citations

[1]Yang L, et al. Benzofuranyl-pyrazole as a Novel Scaffold for In Vitro and In Vivo Potent Anticancer Therapeutics That Directly Disrupt the 'Undruggable' MYC Oncogene and Potentiate Immune Checkpoint Blockage. J Med Chem. 2025 Sep 25;68 (18) :19184-19204.