BTR2038

BTR2038 is a BRD9 degrader. BTR2038 consistis of a BRD9 bromodomain ligand (Bl-7273 analoag), a linker and BTR2000. BTR2038 induces targeted degradation of V5-tagged human BRD9. BTR2038 can be used for the study of biological processes and diseases associated with abnormal BRD9 protein function[1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain

Related Pathways

Epigenetics

Field of Research

Others

Smiles

O=C(N1CCC[C@@H]1C(N[C@H](CC(O)=O)C(N[C@H](CC(C)C)C(N[C@@H](CSC2)C(N)=O)=O)=O)=O)[C@H](CSC3=CC2=CC=C3)NC(CCCNCC4=C(OC)C=C(C5=CN(C)C(C6=C5C=CN=C6)=O)C=C4OC)=O

Molecular Formula

C50H63N9O11S2

Molecular Weight

1030.22

References & Citations

[1]Phoebe H, et al. Temporal and Spatial Characterization of CUL3KLHL20-Driven Targeted Degradation of BET Family BRD Proteins by the Macrocycle-Based Degrader BTR2004. ACS Chem. Biol. 2025, 20, 9, 2056–2062.