SS-3091
SS-3091 is a pan KRas inhibitor. SS-3091 binds to the interaction interfaces of KRas, destabilizing the ARaf/KRas complex and thereby influencing downstream signaling transduction. SS-3091 has significant anticancer and antiproliferation activities against the KRas G12D, G12C, G12V, and G12S mutants in various cancer cells[1].
Product Specifications
CAS Number
2756257-56-2
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C)C(C3=CC4=C(C(C)=C3)N=C(NC5=CC=C6C(C(CN(CC6)C)C)=C5)N=C4)=C2
Molecular Formula
C36H34F3N5O
Molecular Weight
609.68
References & Citations
[1]Zeng J, et al. Structure-Based Discovery of Active Pan-KRas Inhibitors Targeting G12D Mutants by Enhanced Sampling Simulations. J Phys Chem B. 2025 Sep 18;129 (37) :9283-9292.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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