Tubulin-IN-56

Tubulin-IN-56 is a tubulin inhibitor. Tubulin-IN-56 exerts cytotoxic effects against colon cancer cell lines (LS180, HCT116, SW620, LoVo) . Tubulin-IN-56 downregulates βIII-tubulin and upregulates βIVa-tubulin in colon cancer cell lines. Tubulin-IN-56 inhibits cell invasiveness and elevates intracellular ROS levels in colon cancer cell lines. Tubulin-IN-56 can be used for the study of colon cancer[1].

Product Specifications

UNSPSC

12352005

Target

Microtubule/Tubulin; Reactive Oxygen Species (ROS)

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

O=C(c1cccc1)N[C@@H](C2=CC=CC=C2)[C@@H](O)C(O[C@H]3C[C@]4(O)C(C)(C)C([C@@H](OC(C)=O)C([C@@]5(C)C([C@@](CO6)(OC(C)=O)[C@H]6C[C@@H]5O)[C@@H]4OC(C7=CC=CC=C7)=O)=O)=C3C)=O.[][Ru][].c8cccc8

Molecular Formula

C51H55NO14Ru

Molecular Weight

1007.05

References & Citations

[1]Ciszewski WM, et al. Ruthenocenyl and 1-Adamantyl Paclitaxel Analogs Disrupt the Balance between βIII- and βIVa-Tubulin and Inhibit the Growth and Invasiveness of Colon Cancer. J Med Chem. 2025 Sep 25;68 (18) :19062-19075.