TLR9 antagonist 1
TLR9 antagonist 1 (Compound 38) is a selective TLR9 antagonist with an IC50 of 0.1 nM for hTLR9 over hTLR2/4/5/7/8. TLR9 antagonist 1 exacerbates disease symptoms with increased anti-dsDNA and anti-Sm levels in systemic lupus erythematosus (SLE) mouse models. TLR9 antagonist 1 can be used for inflammatory and immune diseases like lupus and arthritis research[1].
Product Specifications
CAS Number
3105410-45-2
UNSPSC
12352005
Target
Interleukin Related; TNF Receptor; Toll-like Receptor (TLR)
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
N#CC1=C2N=CC=CC2=C(N3C(CN(CCCCNCC4=CC=CC=C4OC)C5)C5CC3)C=C1
Molecular Formula
C28H33N5O
Molecular Weight
455.59
References & Citations
[1]Song X, et al. Discovery of Potent and Selective Quinoline-Based Toll-like Receptor 9 Antagonists. ACS Med Chem Lett. 2025 Aug 26;16 (9) :1747-1755.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; TLR2; TLR4; TLR7; TLR8; TLR9
Available Sizes
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