ZM484

ZM484 is a potent dual p53-MDM2/TOP1 inhibitor that exhibits antiproliferative and antitumor activity both in vitro and in vivo. ZM484 effectively upregulates p53 and MDM2 proteins and maintains TOP1 inhibitory activity by the release of camptothecin (CPT) and a potent p53-MDM2 inhibitor. ZM484 induces cell cycle arrest and apoptosis by regulating the expression of key apoptosis- and cycle-related proteins, including caspase-3, Bcl-2, and Cyclin B1. ZM484 can be used for colorectal cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Bcl-2 Family; Caspase; Cyclin G-associated Kinase (GAK) ; MDM-2/p53; Topoisomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1C2=C(C=C3C4=NC5=CC=CC=C5C=C4CN31)[C@](OC(OCCSSCCOC(CCOCCOCCOCCOCCNC(C6=CC(OC)=C(NC([C@@H]([C@@H]([C@]7(C8=C(C=C(C=C8)Cl)F)C#N)C9=CC=CC(Cl)=C9F)N[C@H]7CC(C)(C)C)=O)C=C6)=O)=O)=O)(C(OC2)=O)CC

Molecular Formula

C67H72Cl2F2N6O15S2

Molecular Weight

1374.35

References & Citations

[1]Wang C, et al. Discovery of Novel Drug-Conjugate Molecule ZM484 with Dual p53-MDM2 and TOP1 Inhibition for the Treatment of Colorectal Cancer. J Med Chem. 2025 Sep 25;68 (18) :18988-19001.