PROTAC OSBP Degrader-1

PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC50 of 322 nM (24 h) . PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells[1]. Pink: OSBP ligand (HY-178035) ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker

Product Specifications

UNSPSC

12352005

Target

Oxysterol-binding Protein-related Protein (ORP) ; PROTACs

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Field of Research

Cancer

Smiles

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCCCCCN4N=NC(COC5=CC(/C=C/C6=CC7=C(C(OC)=C6)O[C@]8(C)CC[C@@H](O)C(C)(C)[C@@]8([H])C7)=CC(O)=C5C/C=C(C)\C)=C4