PROTAC OSBP Degrader-1
PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC50 of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells[1]. Pink: OSBP ligand ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker
Product Specifications
UNSPSC
12352005
Target
Oxysterol-binding Protein-related Protein (ORP) ; PROTACs
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
Molecular Formula
C56H68N6O12
Molecular Weight
1017.17
References & Citations
[1]Guimard C, et al. Elaboration and profiling of the first OSBP degrader issued from natural Schweinfurthins. Bioorg Chem. 2025 Sep;164:108909.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
HLA-Aw32 & HLA-A25 (MHC I) (CATA-1), CF740 conjugate, 0.1mg/mL
Mucin 5AC (MUC5AC) (45M1), CF640R conjugate, 0.1mg/mL
CD45 / LCA (2B11 + PD7/26), CF405S conjugate, 0.1mg/mL
Renal Cell Carcinoma (Carbonic Anhydrase IX) (66.4.C2), CF740 conjugate, 0.1mg/mL
CD35 / CR1 (E11), CF568 conjugate, 0.1mg/mL
