Antileishmanial agent-35
Antileishmanial agent-35 (Compound 6) is an antileishmanial agent with an IC50 of 0.29μM for promastigotes of Leishmania amazonensis. Antileishmanial agent-35 significantly decreases the mitochondrial membrane potential and ATP levels, and further increases the production of ROS by a blockage in the electron transport chain, where ubiquinone intervenes. Antileishmanial agent-35 can be used for cutaneous leishmaniases research[1].
Product Specifications
CAS Number
[100611-91-4]
UNSPSC
12352005
Target
Mitochondrial Metabolism; Parasite; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection
Smiles
O=C1C(C2CCCCC2)=CC(C(C)=C1)=O
Molecular Formula
C13H16O2
Molecular Weight
204.26
References & Citations
[1]García-Davis S, et al. Laurequinone-based synthetic quinones as agents against Leishmania amazonensis. Bioorg Chem. 2025 Sep;164:108897.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-178033/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Leishmania
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