SARS-CoV-2 nsp14-IN-6 (ammonium)
SARS-CoV-2 nsp14-IN-6 (Compound 35) ammonium is a SARS-CoV-2 Nsp14 MTase inhibitor with an IC50 of 0.24 μM. SARS-CoV-2 nsp14-IN-6 ammonium has potent antiviral activity against SARS-CoV-2 replication. SARS-CoV-2 nsp14-IN-6 ammonium increases lipophilicity, further improving cell permeability. SARS-CoV-2 nsp14-IN-6 ammonium can be used for human coronaviruses research[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C([O-])C1=CC=C(C2=NN(C3=CC=C(C#N)C(Cl)=C3)C(CC)C2)C(C)=C1.[NH4+]
Molecular Formula
C20H21ClN4O2
Molecular Weight
384.86
References & Citations
[1]Smyth E B, et al. Design and Synthesis of Pyrazoline Inhibitors of SARS-CoV-2 NSP14[J]. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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