SARS-CoV-2 nsp14-IN-6
SARS-CoV-2 nsp14-IN-6 (Compound 35) is a SARS-CoV-2 Nsp14 MTase inhibitor with an IC50 of 0.24 μM. SARS-CoV-2 nsp14-IN-6 has potent antiviral activity against SARS-CoV-2 replication. SARS-CoV-2 nsp14-IN-6 increases lipophilicity, further improving cell permeability. SARS-CoV-2 nsp14-IN-6 can be used for human coronaviruses research[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(O)C1=CC=C(C2=NN(C3=CC=C(C#N)C(Cl)=C3)C(CC)C2)C(C)=C1
Molecular Formula
C20H18ClN3O2
Molecular Weight
367.83
References & Citations
[1]Smyth EB, et al. Design and Synthesis of Pyrazoline Inhibitors of SARS-CoV‑2 NSP14. ACS Med Chem Lett. 2025 Sep 5;16 (10) :1918-1926.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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