TDI-014925

TDI-014925 (Compound 58) is a SARS-CoV-2 methyltransferase nonstructural protein 14 (NSP14) inhibitor with an IC50 of 0.2 nM. TDI-014925 has an antiviral activity with significant microsomal stability and no CYP inhibitory activity. TDI-014925 can be used for COVID-19 research[1].

Product Specifications

CAS Number

[3052313-53-5]

UNSPSC

12352005

Target

SARS-CoV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CC1=C(C=C(N1C)C(NCC2=C3C(C=NN3C)=CC=C2F)=O)S(=O)(N4CCC5=NNC=C5C4)=O

Molecular Formula

C22H24FN7O3S

Molecular Weight

485.53

References & Citations

[1]Miller MW, et al. Discovery, Optimization, and Evaluation of Non-Nucleoside SARS-CoV-2 NSP14 Inhibitors. J Med Chem. 2025 Sep 25;68 (18) :19076-19106.