FLT3-IN-34

FLT3-IN-34 is a FLT3 inhibitor, with an IC50 value of 1.4 nM. FLT3-IN-34 blocks the phosphorylation of FLT3 and its downstream signaling molecules AKT and ERK1/2. FLT3-IN-34 induces concentration-dependent G0/G1 phase arrest and mild apoptosis in FLT3-ITD-positive MV4-11 cells. FLT3-IN-34 shows potent anti-proliferative activity against FLT3-ITD-positive MV4-11 cells (IC50 = 14.95 nM) and MOLM-13 (IC50 = 18.5 nM) . FLT3-IN-34 can be used for the study of FLT3-positive acute myeloid leukemia (AML) [1].

Product Specifications

CAS Number

[3020729-11-4]

UNSPSC

12352005

Target

Akt; Apoptosis; ERK; FLT3

Related Pathways

Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(C(C2=CN=C3C=C(C)C=CN32)=O)C=C1)NC4=NOC(C(C)(C)C)=C4

Molecular Formula

C23H23N5O3

Molecular Weight

417.46

References & Citations

[1]Huang Q, et al. Machine learning-aided design, synthesis and biological evaluation of novel 4- (imidazo[1,2-a]pyridine-3‑carbonyl) phenyl urea derivatives as potent FLT3 inhibitors. Bioorg Chem. 2025 Sep;164:108912.