NDM-1-IN-10
NDM-1-IN-10 (Compound CS-23) is an irreversible and covalent New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 36 nM. NDM-1-IN-10 shows a synergistic effect with Meropenem (HY-13678) against NDM-1-expressing E. coli (MIC of 0.25 μg/mL for E. coli BL21/pET15b-blaNDM-1) . NDM-1-IN-10 can be used for bacterial infections research[1].
Product Specifications
CAS Number
[3044733-61-8]
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=S(C(C1=COC2=C(C=CC(SC3=CC4=CC=CC=C4S3)=C2)C1=O)O)(O[Na])=O
Molecular Formula
C18H11NaO6S3
Molecular Weight
442.46
References & Citations
[1]Liang Y, et al. A synergistic-available and high-potent New Delhi metallo-β-lactamase-1 (NDM-1) covalent inhibitor by the modification of naturally occurring 3-formyl chromone. Bioorg Chem. 2025 Sep;164:108902.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Metallo-β-lactamase (MBL)
Curated Selection
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