D574-0246
D574-0246 is a dual-activity inhibitor of OXCT1, inhibiting both the ketolytic and succinyltransferase activities of OXCT1. D574-0246 reduces substrate-specific (LACTB K284) and global protein succinylation and decreases OXCT1 ketolytic activity in HepG2 cells. D574-0246 inhibits the viability of HCC cells (IC50: 16.49 μM in PLC cells, 6.656 μM in HepG2 cells) . D574-0246 exerts anti-tumor efficacy in nude mice bearing OXCT1-overexpressing HepG2 xenograft tumors. D574-0246 can be used for the study of hepatocellular carcinoma (HCC) [1].
Product Specifications
CAS Number
1269110-12-4
Product Name Alternative
IOXCT1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Mitochondrial Metabolism
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Concentration
10mM
Purity
99.9500
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=C(C=C1)NC2=NC(N3CCN(CC3)C(NC4=CC=C5OCOC5=C4)=O)=CC(C)=N2
Molecular Formula
C24H26N6O3
Molecular Weight
446.50
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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