D574-0246

D574-0246 is a dual-activity inhibitor of OXCT1, inhibiting both the ketolytic and succinyltransferase activities of OXCT1. D574-0246 reduces substrate-specific (LACTB K284) and global protein succinylation and decreases OXCT1 ketolytic activity in HepG2 cells. D574-0246 inhibits the viability of HCC cells (IC50: 16.49 μM in PLC cells, 6.656 μM in HepG2 cells) . D574-0246 exerts anti-tumor efficacy in nude mice bearing OXCT1-overexpressing HepG2 xenograft tumors. D574-0246 can be used for the study of hepatocellular carcinoma (HCC) [1].

Product Specifications

CAS Number

[1269110-12-4]

Product Name Alternative

IOXCT1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Mitochondrial Metabolism

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Concentration

10mM

Purity

99.9500

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1)NC2=NC(N3CCN(CC3)C(NC4=CC=C5OCOC5=C4)=O)=CC(C)=N2

Molecular Formula

C24H26N6O3

Molecular Weight

446.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Liu R, et al. High-throughput screening identifies a dual-activity inhibitor of OXCT1 for hepatocellular carcinoma therapy. Bioorg Chem. 2025 Sep 5;165:108964.