BChE/hCA II-IN-1

BChE/hCA II-IN-1 (Compound 20) is a dual-functional inhibitor of Butyrylcholinesterase (BChE) and human carbonic anhydrase II (hCA II) with IC50s of 76.50 and 10.69 μM for BChE and hCA II, respectively. BChE/hCA II-IN-1 can be used for neurodegenerative diseases like Alzheimer's and glaucoma research[1].

Product Specifications

UNSPSC

12352100

Target

Carbonic Anhydrase; Cholinesterase (ChE)

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC(C)C[C@@H](C(O)=O)NS(=O)(C1=CC(S(=O)(N[C@@H](C(O)=O)CC(C)C)=O)=C(C)C=C1OC)=O

Molecular Formula

C20H32N2O9S2

Molecular Weight

508.61

References & Citations

[1]Canoğlu U, et al. Synthesis of novel benzene bissulfonamides with carbonic anhydrase and choline esterase inhibitory properties. Bioorg Chem. 2025 Aug 31;165:108938.