THR-β agonist 11

THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases[1].

Product Specifications

CAS Number

[3051970-23-8]

UNSPSC

12352005

Target

Thyroid Hormone Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

CC1=CC(OC[P@]2(OCC[C@H](O2)C3=CC=CC(Cl)=C3)=O)=CC(C)=C1CC4=NNC(C(C(C)C)=C4)=O

Molecular Formula

C26H30ClN2O5P

Molecular Weight

516.95

References & Citations

[1]Lin C, et al. Design, synthesis, and biological evaluation of liver-targeting phosphoric acid thyroid hormone receptor agonists for the treatment of metabolic dysfunction-associated steatohepatitis. Bioorg Chem. 2025 Sep;164:108880.