SIK1-IN-1
SIK1-IN-1 (Compound 27) is a selective Salt-inducible kinase 1 (SIK1) inhibitor with an IC50 of 0.7 nM for SIK1 over SIK2 and SIK3. SIK1-IN-1 has no cytotoxicity against HEK293 cells and PBMCs (maximum concentration of 30 μM) . SIK1-IN-1 also has potent inhibitory activities for 392 kinases, in particular tyrosine kinases, such as FGR, HCK and LYN) [1].
Product Specifications
UNSPSC
12352005
Target
Salt-inducible Kinase (SIK) ; Src
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Field of Research
Others
Smiles
COC1=CN2C(C(NC3=C(C=C(C=C3C)Cl)C)=O)=CN=C2C=C1C4=NN(C=C4)C
Molecular Formula
C21H20ClN5O2
Molecular Weight
409.87
References & Citations
[1]Peixoto C, et al. Structure activity relationship exploration of imidazo[1,2-a]pyridine series to reverse isoform selectivity and identify potent SIK1 selective inhibitors. Bioorg Med Chem Lett. 2025 Dec 15;129:130397.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Fgr; Hck; Lck; Lyn; SIK1; SIK2; SIK3; Yes
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