SIK1-IN-1

SIK1-IN-1 (Compound 27) is a selective Salt-inducible kinase 1 (SIK1) inhibitor with an IC50 of 0.7 nM for SIK1 over SIK2 and SIK3. SIK1-IN-1 has no cytotoxicity against HEK293 cells and PBMCs (maximum concentration of 30 μM) . SIK1-IN-1 also has potent inhibitory activities for 392 kinases, in particular tyrosine kinases, such as FGR, HCK and LYN) [1].

Product Specifications

UNSPSC

12352005

Target

Salt-inducible Kinase (SIK) ; Src

Related Pathways

Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Field of Research

Others

Smiles

COC1=CN2C(C(NC3=C(C=C(C=C3C)Cl)C)=O)=CN=C2C=C1C4=NN(C=C4)C

Molecular Formula

C21H20ClN5O2

Molecular Weight

409.87

References & Citations

[1]Peixoto C, et al. Structure activity relationship exploration of imidazo[1,2-a]pyridine series to reverse isoform selectivity and identify potent SIK1 selective inhibitors. Bioorg Med Chem Lett. 2025 Dec 15;129:130397.