ROCK2-IN-11
ROCK2-IN-11 (Compound A20) is a selective ROCK2 inhibitor with an IC50 of 0.18 μM for ROCK2 over ROCK1. ROCK2-IN-11 can be used for idiopathic pulmonary fibrosis and cGVHD research[1].
Product Specifications
UNSPSC
12352005
Target
ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Smiles
COC1=CC(C(N2CCC(CC2)C(N3CCC(CC3)C4=CC=CC=C4)=O)=O)=CC=C1C5=CNN=C5
Molecular Formula
C28H32N4O3
Molecular Weight
472.58
References & Citations
[1]Wang J, et al. Discovery of A20 with 4- (2-methoxyphenyl) -1H-pyrazole scaffold as a potent and selective ROCK2 inhibitor. Bioorg Med Chem Lett. 2025 Dec 15;129:130391.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK1; ROCK2
Curated Selection
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