CDK2 degrader 8
CDK2 degrader 8 (Compound1) is a CDK2 degrader. CDK2 degrader 8 shows potential anti-tumor activity by targeting CDK2. CDK2 degrader 8 can be used for the study of solid tumors (breast cancer, triple negative breast cancer, ovarian serous cystadenocarcinoma) and liquid tumors (diffuse large B-cell lymphoma, acute myelogenous leukemia) associated with abnormal CDK2 function[1].
Product Specifications
CAS Number
[3099145-52-2]
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
FC(F)(OC1=CC=C(C2=NN=C(O2)NC3(CC3)C4=CC(Cl)=C5CN(C(C5=C4)=O)C6CCC(NC6=O)=O)C=C1)F
Molecular Formula
C25H19ClF3N5O5
Molecular Weight
561.90
References & Citations
[1]FASCHING, et al. Cyclopropyl and 1,3,4-Oxadiazole Compounds That Mediate Protein Degradation and Methods of Use Thereof. WO 2025/181261 A1. World Intellectual Property Organization (WIPO) . 04 September 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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