MRS4917
MRS4917 is an orally active, potent selective P2Y14 receptor (hP2Y14R) antagonist (IC50 = 2.88 nM, Ki = 1.67 nM) that shows >18,000 fold selectivity against P2Y6R (IC50 = 54 μM) . MRS4917 demonstrates oral efficacy in reversing established mechanoallodynia in the chronic constriction injury (CCI) mouse model, while having no effect on thermoregulation. MRS4917 can be used for neurological diseases research[1].
Product Specifications
UNSPSC
12352005
Target
P2Y Receptor
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(O)C1=CC(C2=CC=C(C3=NNC=C3)C=C2)=C4C=CC(C5=CC=C(C(F)(F)F)C=C5)=CC4=C1
Molecular Formula
C27H17F3N2O2
Molecular Weight
458.43
References & Citations
[1]Pramanik A, et al. P2Y14 Receptor Antagonists: Piperidine Bioisosteres and Mutagenesis-Supported Molecular Modeling. ACS Pharmacol Transl Sci. 2025 Aug 25;8 (9) :3126-3148.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y14 Receptor; P2Y6 Receptor
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