Tubulin polymerization-IN-87
Tubulin polymerization-IN-87 (Compound 9) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-87 disrupts tubulin polymerization and induces G2/M cell cycle arrest. Tubulin polymerization-IN-87 exhibits anti-tubulin and anti-proliferative effects. Tubulin polymerization-IN-87 exhibits anticancer activity against ovarian cancer[1].
Product Specifications
CAS Number
[2035931-43-0]
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
COC1=CC(N2[C@H]([C@H](C2=O)C)C3=CC(O)=C(OC)C=C3)=CC(OC)=C1OC
Molecular Formula
C20H23NO6
Molecular Weight
373.40
References & Citations
[1]Zhou P, et al. Potent Antitumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin. J Med Chem. 2016 Nov 23;59 (22) :10329-10334.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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