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Tubulin polymerization-IN-87

Tubulin polymerization-IN-87 (Compound 9) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-87 disrupts tubulin polymerization and induces G2/M cell cycle arrest. Tubulin polymerization-IN-87 exhibits anti-tubulin and anti-proliferative effects. Tubulin polymerization-IN-87 exhibits anticancer activity against ovarian cancer[1].

Product Specifications

CAS Number

2035931-43-0

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

COC1=CC(N2[C@H]([C@H](C2=O)C)C3=CC(O)=C(OC)C=C3)=CC(OC)=C1OC

Molecular Formula

C20H23NO6

Molecular Weight

373.40

References & Citations

[1]Zhou P, et al. Potent Antitumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin. J Med Chem. 2016 Nov 23;59 (22) :10329-10334.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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