α4β7 Integrin-IN-1
α4β7 Integrin-IN-1 (Example 356) is a potent inhibitor of α4β7 integrin (integrin) . Its ability to block the interaction between α4β7 integrin and MadCAM-1 (EC50) is 0.05 nM. α4β7 Integrin-IN-1 can be used for the study of inflammatory bowel disease[1].
Product Specifications
CAS Number
[2417307-52-7]
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CN(C(N1C2=CC=C(C3=C2N=CC=C3)C[C@H](NC(C(C(F)=C4)=C(C)C=C4N5CCOC[C@@H]5C(F)(F)F)=O)C(O)=O)=O)C6=CN=CC=C6C1=O
Molecular Formula
C33H28F4N6O6
Molecular Weight
680.61
References & Citations
[1]Peter A, et al. Quinoline derivatives as alpha4beta7 integrin inhibitors. WO2020092375A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α4β7
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
