Mal-PEG2-Val-Arg-PABC-OMe-Eribulin
Mal-PEG2-Val-Arg-PABC-OMe-Eribulin (Compound L-1) is a drug-linker conjugate composed of O-Me Eribulin (HY-159576) and the linker Mal-PEG2-Val-Cit-PAB-OH (HY-130222) . Mal-PEG2-Val-Arg-PABC-OMe-Eribulin can be used to synthesize anti-HER3/MET antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[2676196-79-3]
UNSPSC
12352005
Target
C-Met/HGFR; Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C=C1C[C@](O[C@@]1([H])CC[C@](C[C@H]2C)([H])O[C@](C2=C)([H])C[C@@](O[C@@H]3C[C@H](OC)CNC(OCC(C=C4)=CC=C4NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN(C5=O)C(C=C5)=O)=O)=O)=O)=O)([H])[C@]([C@H]3OC)([H])CC6=O)([H])CC[C@@]7(C[C@@]8([H])O9)O[C@]([C@](O[C@](C6)([H])CC%10)([H])[C@@]%10([H])O%11)([H])[C@@]9([H])[C@]%11([H])[C@@]8([H])O7
Molecular Formula
C71H101N7O21
Molecular Weight
1388.60
References & Citations
[1]Li, et al. Her3/met binding molecule and pharmaceutical use thereof. WO2025056029A1. WIPO (PCT) . 2024-09-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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