GRK2 degrader-1
GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. GRK2 degrader-1 degrades GRK2 via the ubiquitin-proteasome pathway. GRK2 degrader-1 inhibits right ventricular remodeling and elevation of pulmonary artery pressure in a pulmonary artery hypertension (PAH) mouse model. GRK2 degrader-1 can be used for PAH research[1].
Product Specifications
CAS Number
[3052947-04-0]
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK)
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(CC1=CC=C2C(C(N(C3C(NC(CC3)=O)=O)C2)=O)=C1)NC4=NC=C(CC5=CC=CC=C5)S4
Molecular Formula
C25H22N4O4S
Molecular Weight
474.53
References & Citations
[1]Zuling XU, et al. G protein-coupled receptor kinase 2 (grk2) degradation compounds and use thereof. WO2024165075. 2024-08-15
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GRK2
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