MS99-β-Gal

MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC50 of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC50 = 2.162 μM) . MS99-β-Gal can be used for the research of cancer[1].

Product Specifications

CAS Number

3055593-63-7

Product Name Alternative

Gal-MS99

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; PROTACs

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

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