MS99-β-Gal
MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC50 of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC50 = 2.162 μM) . MS99-β-Gal can be used for the research of cancer[1].
Product Specifications
CAS Number
3055593-63-7
Product Name Alternative
Gal-MS99
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; PROTACs
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
Molecular Formula
C78H96ClN9O20S2
Molecular Weight
1579.23
References & Citations
[1]Chang M, et al. Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs. J Med Chem. 2024 May 9;67 (9) :7301-7311.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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