NAE-IN-3
NAE-IN-3 (compound 1) is a potent, selective and non-covalent competitive NEDD8-activating enzyme (NAE) inhibitor (IC50 = 0.8 μM) . NAE-IN-3 inhibits NAE by blocking the ATP-binding domain. NAE-IN-3 exhibits selectivity over analogous E1 enzymes UAE and SAE. NAE-IN-3 can be used for cancer research[1].
Product Specifications
CAS Number
[951950-33-7]
UNSPSC
12352005
Target
NEDD8-activating Enzyme
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(CNC(CNC(COC1=CC2=C(N=C3N(CCC3)C2=O)C=C1)=O)=O)O
Molecular Formula
C17H18N4O6
Molecular Weight
374.35
References & Citations
[1]Zhong HJ, et al. Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening. Biochimie. 2012 Nov;94 (11) :2457-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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