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MNOX-E36

MNOX-E36 is a murine-specific analogue of NOX-E36 , an anti-CCL-2 L-RNA aptamer that binds and neutralises the mouse chemokine CCL-2. mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery (GFS). mNOX-E36 ameliorates lupus nephritis in mice. mNOX-E36 can be used for GFS and lupus nephritis research[1][2].

Product Specifications

UNSPSC

12352208

Target

CCR

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

[mNOX-E36]

References & Citations

[1]Kulkarni O, et al. Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL- (Fas) lpr mice. J Am Soc Nephrol. 2007 Aug;18 (8) :2350-8.|[2]Lim ST, et al. Inhibition of chemokine MCP-1 with mNOX-E36 reduces scarring in a mouse model of glaucoma filtration surgery. Exp Eye Res. 2026 Jan;262:110735.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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