MEK-IN-7
MEK-IN-7 (compound WX086) is potent, orally active and selective MEK inhibitor (MEK1 IC50 = 29.62 nM) . MEK-IN-7 inhibits HT29 and A375 cell proliferation with IC50s of 0.62 and 0.40 nM. MEK-IN-7 inhibits tumor growth in a HL-29 xenograft mouse model. MEK-IN-7 can be used for melanoma and colon cancer research[1].
Product Specifications
CAS Number
2256822-22-5
UNSPSC
12352005
Target
MEK
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=C1OC2=C(C(NC3=CC=C(C=C3F)I)=C1C)C(N(C4CC4)C(C)=C2C5=C(C)C(NS(C)(=O)=O)=CC=C5)=O
Molecular Formula
C27H25FIN3O5S
Molecular Weight
649.47
References & Citations
[1]Qinghua M, et al. Coumarin ring-like compound as MEK inhibitor and application thereof. WO2018233696. 2018-12-27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK1
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