OSU-02067

OSU-02067 is a selective 3-phosphoinositide-dependent protein kinase-1 (PDK-1) inhibitor (IC50=9 μM) . OSU-02067 is promising for research of solid tumors (e.g., prostate, breast, colorectal cancers) [1].

Product Specifications

CAS Number

[618068-98-7]

UNSPSC

12352005

Target

PDK-1

Related Pathways

PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=S(N)(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC(C=CC4=C5C=CC=C4)=C5C=C3)C=C1)=O

Molecular Formula

C24H16F3N3O2S

Molecular Weight

467.46

References & Citations

[1]Zhu J, et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004 Jun 15;64 (12) :4309-18. doi: 10.1158/0008-5472.CAN-03-4063. Erratum in: Cancer Res. 2019 Apr 1;79 (7) :1716.