SH-273

SH-273 is a dual targeting compound. SH-273 has dual function to stimulate STING function (EC50: 100 nM) and inhibits PI3Kγ (IC50: 7 nM) . SH-273 can be used in the research of pancreatic cancer[1].

Product Specifications

CAS Number

[3084159-97-4]

UNSPSC

12352005

Target

PI3K; STING

Related Pathways

Immunology/Inflammation; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C1C(C2=C3)=C(C(N1CCC(OCCN4C=C(C5=C6C(C=C(N(C7=CC=CC=C7)C6=O)[C@H](C)NC(C8=C9N(C=CC=N9)N=C8N)=O)=CC=C5)N=N4)=O)=O)SC2=CC(OC)=C3OC

Molecular Formula

C43H36N10O8S

Molecular Weight

852.87

References & Citations

[1]Li C, et al. Overcoming B regulatory cell induced STING resistance by dual functional albumin nanomedicine to prolong survival of pancreatic cancer. Cancer Research, 2024, 84 (6_Supplement) : 6534-6534.